Hydrangea macrophylla is a flowering plant that changes color of the bloom in response to soil pH. Ferdoush et al. demonstrate a metaphorical mimicry of such a phenomenon at the level of gene activation, where the activator in budding yeast functionally alternates between coactivators, SAGA and NuA4, in response to inorganic phosphate in the growth medium to promote transcription of a high-affinity inorganic phosphate transporter gene, PHO84. Image courtesy of Arpan Roy. See Ferdoush et al. GENETICS 208: 191–205.

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Image: Matt Sachs, Agility Images

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Help us build the future: GSA’s 2019 Appeal Campaign

“It’s been incredible to see such a strong response from leaders in the genetics community — rallying together to ensure GSA will have the resources needed to sustain and build upon its legacy. We are humbled by their generosity and know it will inspire the community to participate in this important effort.”

-Terry R. Magnuson, 2019 GSA President and Annual Appeal Co-Chair

Help GSA sustain and grow its cornerstone programs and projects: travel awards, career development programs, journals, and conferences. The 2019 Annual Appeal offers a mechanism through which our professional community can give back—both to the field of genetics and to an organization that has positively impacted the lives and careers of thousands of scientists.

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Community Voices

In memory of David Hogness

Guest post by from Kenneth C. Burtis (University of California, Davis) and Mariana F. Wolfner (Cornell University). We note with great sadness the death of one of the giants of 20th century genetics, David Swenson Hogness, who passed away in Stanford, California on December 24, 2019 at the age of 94. The title of this blog, Genes […]

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by Guest Author

Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants

Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair. Earlier work demonstrated that heparan sulfate proteoglycans, an abundant class of carbohydrate-modified proteins found on cell surfaces and in the extracellular matrix, suppress basal levels of autophagy in several cell types during development in Drosophila melanogaster. In studies reported here, we examined the capacity...

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by Reynolds-Peterson, C., Xu, J., Zhao,...

Close-up view of a wild-type Junonia coenia wing eyespot pattern. Zhang et al. used CRISPR mutagenesis to interfere with the genetic machinery necessary for making melanin pigments in the colored scales of the butterfly wing. See Zhang et al.

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Jennifer Solis, Northwestern University

It was critical that GSA was so willing to put their faith in us. Many people didn’t initially have a lot of confidence that a group of postdocs could organize a new event of this scale.

Sarah Dykstra, Career Development Symposium funding recipient
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