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Guest post by Alyssa Scott, Amanda Engstrom, and Teresa Lee. As scientists, we know that social distancing is the best way to combat COVID-19. But as human beings, we’ve found that social distancing is an efficient way to quickly drain our mental health. We have a friend who, Castaway-style, puts a sticky note on the […]
The Physical Mechanisms of Drosophila Gastrulation: Mesoderm and Endoderm Invagination [Development and Growth]
A critical juncture in early development is the partitioning of cells that will adopt different fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is achieved through the internalization of specified cells from the outermost surface layer, through a process called gastrulation. In Drosophila, gastrulation is achieved through cell shape changes (i.e., apical constriction) that change tissue curvature and lead to the folding of a surface epithelium. Folding of embryonic...
Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity
There has been extensive discussion of the "Replication Crisis" in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross between two inbred strains. We re-genotyped a previously published cohort of LG/J x SM/J AIL mice (F34; n = 428) using a denser marker set and genotyped a new cohort of AIL mice (F39-43; n = 600) for the first...
It was critical that GSA was so willing to put their faith in us. Many people didn’t initially have a lot of confidence that a group of postdocs could organize a new event of this scale.Learn more