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Read the latest from GENETICS Early Online

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins [Investigation]

Cross-species complementation can be used to generate humanized yeast, which is a valuable resource with which to model and study human biology. Humanized yeast can be used as an in vivo platform to screen for chemical inhibition of human protein drug targets. To this end, we report the systematic complementation of nonessential yeast genes implicated in chromosome instability (CIN) with their human homologs. We identified 20 human-yeast complementation pairs that are replaceable in 44 assays...

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by Hamza, A., Driessen, M. R....

Differential Contributions of DNA Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene [Investigation]

Polycomb-group (PcG) proteins are evolutionarily conserved epigenetic regulators whose primary function is to maintain the transcriptional repression of target genes. Recruitment of Drosophila melanogaster PcG proteins to target genes requires the presence of one or more Polycomb Response Elements (PREs). The functions or necessity for more than one PRE at a gene are not clear and individual PREs at some loci may have distinct regulatory roles. Various combinations of sequence-specific DNA binding proteins are present...

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by Ghotbi, E., Lackey, K., Wong,...

Sex Chromosome Pairing Mediated by Euchromatic Homology in Drosophila Male Meiosis [Investigation]

Diploid germline cells must undergo two consecutive meiotic divisions before differentiating as haploid sex cells. During meiosis I, homologs pair and remain conjoined until segregation at anaphase. Drosophila melanogaster spermatocytes are unique in that the canonical events of meiosis I including synaptonemal complex (SC) formation, double-strand DNA breaks, and chiasmata are absent. Sex chromosomes pair at intergenic spacer sequences within the rDNA. Autosomes pair at numerous euchromatic homologies, but not at heterochromatin, suggesting that pairing...

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by Hylton, C. A., Hansen, K.,...