Hydrangea macrophylla is a flowering plant that changes color of the bloom in response to soil pH. Ferdoush et al. demonstrate a metaphorical mimicry of such a phenomenon at the level of gene activation, where the activator in budding yeast functionally alternates between coactivators, SAGA and NuA4, in response to inorganic phosphate in the growth medium to promote transcription of a high-affinity inorganic phosphate transporter gene, PHO84. Image courtesy of Arpan Roy. See Ferdoush et al. GENETICS 208: 191–205.

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Community Voices

Adjusting to life in isolation

As COVID-19 spreads across the world, members of the GSA community have had to face unprecedented challenges in their professional and personal lives. To stay connected during this socially distant time, GSA invites the scientists in our community to share how they are meeting these challenges, as well as their questions and worries.  If you […]

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by Guest Author

The Physical Mechanisms of Drosophila Gastrulation: Mesoderm and Endoderm Invagination [Development and Growth]

A critical juncture in early development is the partitioning of cells that will adopt different fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is achieved through the internalization of specified cells from the outermost surface layer, through a process called gastrulation. In Drosophila, gastrulation is achieved through cell shape changes (i.e., apical constriction) that change tissue curvature and lead to the folding of a surface epithelium. Folding of embryonic...

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by Martin, A. C.

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

There has been extensive discussion of the "Replication Crisis" in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross between two inbred strains. We re-genotyped a previously published cohort of LG/J x SM/J AIL mice (F34; n = 428) using a denser marker set and genotyped a new cohort of AIL mice (F39-43; n = 600) for the first...

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by Zhou, X., St. Pierre, C....

Close-up view of a wild-type Junonia coenia wing eyespot pattern. Zhang et al. used CRISPR mutagenesis to interfere with the genetic machinery necessary for making melanin pigments in the colored scales of the butterfly wing. See Zhang et al.

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Jennifer Solis, Northwestern University

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